2018 AANS Annual Scientific Meeting-501. ASL Perfusion Imaging of the Frontal Lobes Predicts the Occurrence and Resolution of Posterior Fossa Syndrome

501. ASL Perfusion Imaging of the Frontal Lobes Predicts the Occurrence and Resolution of Posterior Fossa Syndrome

Video Transcription

Video Summary

In this video, Dr. Derek Yeses discusses ASL perfusion imaging of the frontal lobes and its correlation with the occurrence and resolution of posterior fossa syndrome (PFS) following posterior fossa tumor surgery in children. PFS is a complication that can lead to a range of symptoms beyond cerebellar dysfunction, including mutism, emotional disturbances, and behavioral symptoms. Previous studies have suggested that PFS is associated with damage to the cerebellar efferent pathways. Using ASL perfusion imaging, Dr. Yeses and his team found decreased frontal lobe perfusion in patients who developed PFS compared to those who did not. They also observed increased perfusion in the frontal lobes following the resolution of PFS symptoms. The results support the theory of cerebellocerebral diaschesis as the underlying cause of PFS. This study highlights the potential use of ASL perfusion imaging as a biomarker for identifying patients at risk for PFS and monitoring its resolution. While the study has some limitations, such as its retrospective nature and small sample size, it provides valuable insights into the pathophysiology of PFS and opens up possibilities for future research and treatments.

Asset Caption

Derek Yecies, MD

Keywords

ASL perfusion imaging

frontal lobes

posterior fossa syndrome

PFS

cerebellocerebral diaschesis