2018 AANS Annual Scientific Meeting-506. Genotype Based Local Targeted Therapy for Glioma

506. Genotype Based Local Targeted Therapy for Glioma

Video Transcription

Video Summary

Dr. Ganesh Shankar presents his talk titled "Genotype-Based Local Targeted Therapy for Glioma" as the winner of the Mahaly Clinical Research Award. He discusses the need for improved treatment strategies for patients with glioma, specifically focusing on diffuse astrocytomas. Dr. Shankar introduces a rapid protocol for genotyping glioma-specific mutations within an intraoperative timeframe. He also explains the development of a sustained release formulation of NAMPT inhibitors using a biodegradable copolymer, which can be applied locally at the surgical margin. In in vivo studies, this formulation showed efficacy in reducing tumor volume growth and increasing overall survival. Dr. Shankar acknowledges the collaborative effort of his team and their collaborators at MIT.

Asset Caption

Ganesh Mani Shankar, MD

Keywords

Genotype-Based Local Targeted Therapy for Glioma

Mahaly Clinical Research Award

diffuse astrocytomas

genotyping glioma-specific mutations

sustained release formulation of NAMPT inhibitors