2018 AANS Annual Scientific Meeting-507. Analysis of Mutational Processes in 23 Adult Hemispheric Diffuse Gliomas Identifies DNA-Damage Repair Deficiency as a Major Contributor to Gliomagenesis.

507. Analysis of Mutational Processes in 23 Adult Hemispheric Diffuse Gliomas Identifies DNA-Damage Repair Deficiency as a Major Contributor to Gliomagenesis.

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Video Summary

Dr. Ozdemir presents an analysis of mutational processes in adult hemispheric diffuse gliomas, identifying DNA damage repair deficiency as a major contributor to glioma genesis. The study analyzes the signatures of mutational processes in each tumor case and finds that gliomas have a unique collection of mutational signatures. Common signatures are attributed to aging and DNA damage repair defects, which are more prevalent in younger patients and may be inherited or acquired. The study suggests that heredity plays a role in glioma cases. The findings have clinical relevance as they help understand the causes and potential treatments for gliomas. The transcript is from a presentation by Dr. Ozdemir, the recipient of the Brain Lab Neurosurgery Award.

Asset Caption

Koray Ozduman, MD (Turkey)

Keywords

mutational processes

gliomas

DNA damage repair deficiency

mutational signatures

heredity