2018 AANS Annual Scientific Meeting-509. Whole Exome and Targeted Sequencing of Adult Infiltrating Astrocytomas: Experience at a Single Institution

509. Whole Exome and Targeted Sequencing of Adult Infiltrating Astrocytomas: Experience at a Single Institution

Video Transcription

Video Summary

In this video, Rohan Ramakrishna presents his research on whole exome sequencing of adult infiltrating astrocytomas. He discusses the different types of astrocytomas and their molecular markers, as well as the genomic landscape of gliomas. The presentation also highlights the need for individualized therapy in gliomas and the goals of the study, including establishing a precision medicine pipeline, comparing results with commercially available platforms, and assessing the value of whole exome sequencing. The research identifies commonly reported mutations in astrocytomas and explores less frequent mutations that may impact treatment response and survival. The video concludes with the importance of pipeline assessment and data quality in interpreting tumor mutations.

Asset Caption

Rohan Ramakrishna, MD, FAANS

Keywords

whole exome sequencing

adult infiltrating astrocytomas

molecular markers

genomic landscape

gliomas