2018 AANS Annual Scientific Meeting-512. RNA Deconvolution Reveals Distinctive Immunogenetic Landscapes in Nf2 and non-Nf2 Meningiomas

512. RNA Deconvolution Reveals Distinctive Immunogenetic Landscapes in Nf2 and non-Nf2 Meningiomas

Video Transcription

Video Summary

In this video, Dr. Jackie Young, a fifth-year resident at Yale University, discusses her work on using RNA information to investigate the immunological landscape in meningiomas based on their mutational subtypes. She explains that while most low-grade meningiomas can be resected with low recurrence rates, some cases recur despite radiation therapy and there are no effective medical adjuvant therapies. Dr. Young shares findings from her research, which utilized whole exome sequencing and gene expression analyses on 188 meningiomas. She reveals that NF2 tumors have higher expression of genes related to macrophages, while non-NF2 tumors have higher expression of a gene called tryptase alpha beta 1, which is specific to mast cells. Dr. Young also discusses the use of an algorithm called Cybersort to analyze the overall immune cell composition in the tumors and reveals that the most dominant leukocyte population in human meningiomas is M2 macrophages, known for their immunosuppressive properties. She concludes by emphasizing the importance of considering mutational subtypes and the immune cell composition in developing effective therapies for meningiomas. Dr. Young expresses gratitude to her mentors, funding sources, and patients for their contributions to the studies. No credits were mentioned in the video.

Asset Caption

Jacky Yeung, MD

Keywords

meningiomas

mutational subtypes

immune cell composition

gene expression analyses

therapies