2018 AANS Annual Scientific Meeting-514. Multi-agent vs. Single-agent Intraventricular Chemotherapy for Patients with Neoplastic Meningitis (NM): Changing the Reputation of a Fearsome Disease

514. Multi-agent vs. Single-agent Intraventricular Chemotherapy for Patients with Neoplastic Meningitis (NM): Changing the Reputation of a Fearsome Disease

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Video Summary

In the video, Samer Zamar, a second-year resident at Penn State Neurosurgery, discusses multi-agent versus single-agent interventricular chemotherapy for patients with neoplastic meningitis. Neoplastic meningitis is considered an end-stage disease with a poor survival rate. The use of radiation and systemic chemotherapy has shown some benefits in controlling the primary disease, but intrathecal (IT) chemotherapy has been the standard of care. Zamar compares overall survival between patients receiving multi-agent IT chemotherapy and those receiving single-agent IT chemotherapy. The results show significant survival benefits in patients receiving multi-agent chemotherapy, particularly for patients with solid tumors and lymphoma. The study suggests that further research in a randomized controlled trial is needed to validate these findings.

Asset Caption

Samer Zammar, MD

Keywords

video

Samer Zamar

multi-agent versus single-agent interventricular chemotherapy

neoplastic meningitis

overall survival