2018 AANS Annual Scientific Meeting-515. Integrative Analysis Implicates MYC and MAX in Functional Pituitary Adenomas

515. Integrative Analysis Implicates MYC and MAX in Functional Pituitary Adenomas

Video Transcription

Video Summary

In this video, Douglas Tucker, a second-year medical student at USC, presents an integrative analysis on functional pituitary adenomas. Tucker discusses the differences between growth hormone-secreting and nonfunctional tumors, emphasizing the higher recurrence rate and poorer prognosis associated with growth hormone-secreting tumors. The study focuses on DNA methylation and identifies nine loci of interest with transcription factor binding sites for MYC and MAX. Through motif analysis, the MAX pathway is found to be particularly relevant. Copy number analysis shows increased expression of MAX in growth hormone-secreting tumors. Immunohistochemistry confirms increased expression of both MYC and MAX proteins in these tumors. Tucker concludes that these findings may provide a targetable pathway for the control of patients with acromegaly. The future plans include expanding the immunohistochemistry analysis, investigating the fly-ERG pathway, exploring downstream effects, and studying the inhibition of MYC and MAX. Tucker acknowledges Dr. Zada, Dr. Ghebrezadeh, Dr. John Carmichael, and Dr. Hurth, as well as ANS and USC for their contributions to the project. Overall, the video highlights the research findings regarding MYC and MAX in functional pituitary adenomas and discusses potential avenues for further investigation and treatment.

Asset Caption

Douglass Warren Tucker

Keywords

functional pituitary adenomas

growth hormone-secreting tumors

DNA methylation

transcription factor binding sites

MAX pathway