2018 AANS Annual Scientific Meeting-523. Electrical Stimulation and White Matter Following Spinal Cord Injury in Rats

523. Electrical Stimulation and White Matter Following Spinal Cord Injury in Rats

Video Transcription

Video Summary

Dr. Condyles discusses his graduate studies on electrical stimulation and its potential benefits for white matter modeling after spinal cord injury in rats. He focuses on the corticospinal tract and assesses axonal branching, survivability, demyelination, and potential remyelination. Stimulation of the corticospinal tract is done by implanting electrodes into the motor cortex to invoke forelimb movement. RNA purification and histological analysis show a decrease in the expression of candidate genes involved in node of Ranvier function and maintenance, potentially leading to a decrease in the number of nodes of Ranvier in the corticospinal tract after stimulation. Further research is needed to confirm these findings and explore functional improvement.

Asset Caption

Bethany Kondiles

Keywords

electrical stimulation

white matter modeling

spinal cord injury

corticospinal tract

axonal branching