2018 AANS Annual Scientific Meeting-540. Structural connectivity associated with effective capsulotomy lesion volumes for refractory OCD

540. Structural connectivity associated with effective capsulotomy lesion volumes for refractory OCD

Video Transcription

Video Summary

In this video, Dr. Pranav Nanda discusses their work on the structural connectivity associated with effective capsulotomy lesion volumes for refractory obsessive-compulsive disorder (OCD). They explain that while OCD can be effectively treated with behavioral and medical therapies, neurosurgical interventions like stereotactic radiosurgical capsulotomy can be an option for severe and refractory cases. The purpose of their study was to understand the mechanism of action and predictors of efficacy for capsulotomy by identifying the structural and functional connectomes of effective lesions. They analyzed postoperative MRIs from 28 patients who underwent capsulotomy and used healthy control data sets as proxies for comparison. Through their analysis, they found that the therapeutic mechanism of capsulotomy may involve the modulation of the corticostriatothalamocortical (CSTC) loops and that different imaging modalities capture different aspects of the effects of capsulotomy. Their findings have the potential to improve the preoperative targeting of capsulotomies and ultimately optimize the modulation of salient circuitry for individual patients.

Asset Caption

Pranav Nanda

Keywords

structural connectivity

capsulotomy lesion volumes

refractory obsessive-compulsive disorder

neurosurgical interventions

stereotactic radiosurgical capsulotomy