2018 AANS Annual Scientific Meeting-543. Induction and Quantification of Plasticity in Human Cortical Networks

543. Induction and Quantification of Plasticity in Human Cortical Networks

Video Transcription

Video Summary

The video transcript features Danny, a third-year medical student at Stanford University, presenting a study on the induction and quantification of excitability change in human cortical networks using cortical-cortical evoked potential (CCEP) mapping. The study recruited eight patients with medically intractable epilepsy and recorded the effects of repetitive electrical stimulation on cortical excitability. The results showed both local and distal excitability changes, with some regions exhibiting suppression and others potentiation. The study also found that individual pre-simulation connectivity profiles could accurately predict zones of excitability change. The findings suggest the potential for optimizing non-invasive therapies based on individual characteristics. The study was conducted with support from co-authors Corey Keller and Dr. Ash Mehta at North Shore University Hospital.

Asset Caption

Yuhao Huang

Keywords

excitability change

cortical-cortical evoked potential

medically intractable epilepsy

repetitive electrical stimulation

non-invasive therapies