2018 AANS Annual Scientific Meeting-546. Granger causality analysis reveals a novel thalamic target for DBS treatment of a patient with acquired hemidystonia

546. Granger causality analysis reveals a novel thalamic target for DBS treatment of a patient with acquired hemidystonia

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Video Transcription

Video Summary

In this video, Dr. Afijer Ohayranor discusses grander causality analysis and its application in identifying deep brain stimulation (DBS) targets for patients with secondary dystonia. The speaker explains that DBS target selection is challenging due to variability between patients. To overcome this, the patients undergo chronic recordings using temporary depth electrodes implanted in multiple brain areas. The collected data includes EMG, EEG, local field potential, individual neuron activity, and multi-unit activity. The speaker focuses on one patient with acquired dystonia and analyzes the coherence and Granger causality between brain areas during movement. The results suggest that the VPL nucleus may drive VIM, GPI, and STN in this patient. These findings have implications for DBS treatments and understanding dystonia mechanisms. The video was recorded at Children's Hospital Los Angeles (CHLA) and credit is given to Dr. Afijer Ohayranor and Dr. John.

Asset Caption

Ifije Ohiorhenuan, MD

Keywords

grander causality analysis

deep brain stimulation targets

secondary dystonia

chronic recordings

coherence and Granger causality