2018 AANS Annual Scientific Meeting-564. Vascular Targeting Causing Thrombosis in an Arteriovenous Malformation Animal Model

564. Vascular Targeting Causing Thrombosis in an Arteriovenous Malformation Animal Model

Video Transcription

Video Summary

Andrew Golodin is presenting research on vascular targeting causing thrombosis in an arteriovenous malformation (AVM) animal model. AVMs treatments are successful for some, but newer treatment options are needed for about one-third of cases that are not effectively treated. Golodin proposes using vascular targeting to identify potential targets on the endothelium and administer a protein or antibody to bind to those targets and deliver treatment. The focus of the research is on phosphatidylserine (PS), which translocates to the external surface of vessels in response to radiation. The research shows promising results in causing thrombosis and vessel occlusion in the AVM model using a ligand vascular targeting approach. Dose modification increases selective targeting, making it a potential new treatment option for brain AVMs. Further research is needed to understand target distribution in human AVMs and explore additional targets.

Asset Caption

Andrew Gauden (Australia)

Keywords

vascular targeting

thrombosis

arteriovenous malformation

AVM

treatment options