2018 AANS Annual Scientific Meeting-567. Defining Long-Term Clinical Outcomes and Risks of Stereotactic Radiosurgery (SRS) for Brainstem Cavernous Malformations

567. Defining Long-Term Clinical Outcomes and Risks of Stereotactic Radiosurgery (SRS) for Brainstem Cavernous Malformations

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Video Summary

Dr. Rachel Jacobs from the University of Pittsburgh School of Medicine discusses long-term clinical outcomes and risks of stereotactic radiosurgery (SRS) for brainstem cavernous malformations. The study compares re-bleed rates and outcomes in patients with intrinsic and exophytic cavernous malformations who underwent gamma knife SRS between 1988 and 2016. Results show a significant reduction in annual hemorrhage rate from 31% to 4% during the first two years post-SRS, and further decreased to 2% after two years. Factors such as large target volume, prior surgical resection, and number of hemorrhages before SRS were associated with a higher risk of symptom deterioration and hemorrhage. No significant difference was found between intrinsic and exophytic lesions. The findings suggest that patients with multiple bleeds should undergo early SRS instead of observation.

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Rachel Caroline Jacobs

Keywords

Dr. Rachel Jacobs

University of Pittsburgh School of Medicine

stereotactic radiosurgery

brainstem cavernous malformations

long-term clinical outcomes