2018 AANS Annual Scientific Meeting-568. Phase I clinical trial of intracerebral transplantation using BMSC against acute ischemic stroke

568. Phase I clinical trial of intracerebral transplantation using BMSC against acute ischemic stroke

Video Transcription

Video Summary

In this video, Dr. Kawabara from Japan discusses a phase one clinical trial using autologous bone marrow stromal cells (BMSC) for the treatment of acute ischemic stroke. The study aims to determine the most safe and effective method for this type of treatment. The trial involves using BMSC with no gene modification, a dose of 20 to 50 million cells, and the intracerebral route at the subacute stage. Assessment of motor function and various imaging techniques such as MRI, PET, and spec are used to evaluate the benefits to patients. The trial has recruited patients at day 14 after the ischemic insult, who show complete hemiparesis. The procedure involves using a platelet lysate instead of FBS to expand the stem cells and utilizes stereotactic transplantation. Cell tracking is carried out using magnetic material visible on MRI. The video presents preliminary data from three patients in the trial, showing a decrease in the stem cells over time and some improvement in neurological symptoms. Further investigation is required to assess the safety and effectiveness of this approach. The transcript does not mention any credits granted.

Asset Caption

Masahito Kawabori (Japan)

Keywords

autologous bone marrow stromal cells

acute ischemic stroke

clinical trial

intracerebral route

motor function assessment