2018 AANS Annual Scientific Meeting-571. Wide Bifurcation Morphology Induces Aneurysmogenic High Positive Wall Shear Stress Gradient at the Apex Independent of Flow Rate

571. Wide Bifurcation Morphology Induces Aneurysmogenic High Positive Wall Shear Stress Gradient at the Apex Independent of Flow Rate

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Video Transcription

Video Summary

In this video, Dr. Malik discusses the relationship between bifurcation morphology and the development of aneurysms. They found that aneurysms in the basilar artery and middle cerebral artery were associated with wider bifurcation angles. They also investigated the hemodynamic forces involved, particularly shear stress and shear gradient. They conducted computational fluid dynamic simulations and found that a bifurcation angle of around 85 degrees or higher was associated with the appearance of a positive shear gradient, which is linked to aneurysm development. They also observed these findings in actual patient cases. These results suggest potential therapeutic strategies for addressing aneurysm development by altering unfavorable geometry and understanding endothelial responses.

Asset Caption

Adel M. Malek, MD, PhD, FAANS

Keywords

bifurcation morphology

aneurysm development

shear stress

shear gradient

therapeutic strategies