2018 AANS Annual Scientific Meeting-576. Decompressive Craniectomy Impairs Glymphatic Circulation: Syndrome of the Trephined

576. Decompressive Craniectomy Impairs Glymphatic Circulation: Syndrome of the Trephined

Video Transcription

Video Summary

In this video, Dr. Ben Plagg discusses his research on the glymphatic system in decompressive craniectomy. He presents a case study of a patient who developed symptoms of the syndrome of the trephined following the procedure. Dr. Plagg explains that the glymphatic system plays a role in cerebrospinal fluid and interstitial fluid hydrodynamics and waste clearance in the brain. By using a mouse model, he shows that decompressive craniectomy impairs glymphatic flow, leading to a global suppression of CSF inflow. He also finds that cranioplasty can restore glymphatic function and reduce neuroinflammation. The study suggests that impaired glymphatic flow can result in motor and cognitive deficits.

Asset Caption

Benjamin A Plog, PhD

Keywords

glymphatic system

decompressive craniectomy

glymphatic flow

neuroinflammation

cognitive deficits