2018 AANS Annual Scientific Meeting-597. Temporal lobectomy for seizure control: outcomes and predictors of seizure recurrence

597. Temporal lobectomy for seizure control: outcomes and predictors of seizure recurrence

Video Transcription

Video Summary

In this video, Dr. Johnny Andrews discusses the outcomes and predictors of seizure recurrence in temporal lobectomy for seizure control. The study focused on patients who underwent a standard anterior medial temporal resection between 2000 and 2015 at Yale. The findings showed that the majority of seizure recurrences occurred within the first three years post-surgery. After 10 years, the rate of seizure freedom was 65.6%. Predictors of poor outcome included discordance between preoperative PET and scalp EEG, non-lesional pathology, and selection for intracranial EEG. The study also examined seizure spread and identified a rapid spread phenotype in patients with recurrent seizures. The findings suggest that networks of seizure nodes outside mesial temporal structures may contribute to surgically refractory epilepsy. The implications of these findings include investigating these areas of seizure spread as targets for resection or responsive neurostimulation. The study was funded by HGMI Cure and Dr. Hal Blumenfeld and Dennis Spencer served as mentors for the study. This summary is based on the transcript of a video presentation by Dr. Andrews.

Asset Caption

John Paul Andrews

Keywords

seizure recurrence

temporal lobectomy

seizure control

seizure freedom

surgically refractory epilepsy