2018 AANS Annual Scientific Meeting-600. Subarachnoid Hemorrhage Phosphorylates Neuronal Nitric Oxide Synthase at Ser1412 in the Dentate Gyrus of the Rat Brain

600. Subarachnoid Hemorrhage Phosphorylates Neuronal Nitric Oxide Synthase at Ser1412 in the Dentate Gyrus of the Rat Brain

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Video Transcription

Video Summary

In this video, Dr. Kentaro Wada discusses subarachnoid hemorrhage (SH) in the rat brain and its impact on cognitive function. The study focuses on the hospitalization of neural NOSAT serine-1412 in the SH-RAT model. The speaker explains that cognitive dysfunction is a poor outcome after SH, and previous research shows an influence on the damaged dentate gyrus in the hippocampus. The study investigates chronological and topographical changes in the hospitalization of NNOSAT and PKA at serine-1412 immediately after SH. Results show significant hospitalization of NNOSAT serine-1412 in the hippocampus, particularly in the dentate gyrus. The activation of PK at serine-197 is also observed in the dentate gyrus. The discussion highlights the role of NO in neural dysfunction after SH.

Asset Caption

Kentaro Wada (Japan)

Keywords

subarachnoid hemorrhage

cognitive function

dentate gyrus

hippocampus

neural dysfunction