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OasisLMS
Catalog
2018 AANS Annual Scientific Meeting
604. Genome Wide Analysis of Penumbral Infarction ...
604. Genome Wide Analysis of Penumbral Infarction in Ischemic Stroke
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Video Transcription
Video Summary
Summary: In this video, Dr. Rudy presents research conducted at Brigham and Women's Hospital on the genome-wide analysis of penumbral infarction in ischemic stroke using a mouse model. The study aims to understand the factors that contribute to the rate of infarction in the tissue surrounding the core infarct and potentially identify new therapies. They found significant variation in penumbra volume across different mouse strains and identified 18 genome-wide significant single nucleotide polymorphisms (SNPs) associated with six candidate protein-coding genes related to blood-brain barrier function and resistance to ischemia. Further validation studies are ongoing. The study concludes that penumbra volume varies among mouse strains and is independent of the complete circle of Willis.
Asset Caption
Robert Rudy
Keywords
genome-wide analysis
penumbral infarction
ischemic stroke
mouse model
blood-brain barrier function
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