2018 AANS Annual Scientific Meeting-617. GABAergic Basal Ganglia Output Modulates Tonic and Burst Modes of Thalamic Neurons

617. GABAergic Basal Ganglia Output Modulates Tonic and Burst Modes of Thalamic Neurons

Video Transcription

Video Summary

In this video, Zi Huang, a third year medical student at VCU School of Medicine, discusses the relationship between basal ganglia and thalamus in dystonic models in rodents. Huang explains that dystonic movement is correlated with increased GPI neuron activity and explores the EP VL M1 pathway to establish the pathway being studied. Through various experiments, including injections and optogenetic manipulation, Huang demonstrates that the firing patterns of neurons in the VL thalamus change depending on the activity of the GPI. Huang suggests that modulating the thalamus could be a novel treatment for dystonia, although more research is needed to fully understand the mechanisms behind dystonia and the relationship between different nuclei.

Asset Caption

Zi Ling Huang

Keywords

basal ganglia

thalamus

dystonic models

GPI neuron activity

dystonia treatment