2018 AANS Annual Scientific Meeting-635. Cerebrospinal Fluid Concentrations of Macrophage Migration Inhibitory Factor as a Potential Biomarker of Vasospasm in Subarachnoid Hemorrhage

635. Cerebrospinal Fluid Concentrations of Macrophage Migration Inhibitory Factor as a Potential Biomarker of Vasospasm in Subarachnoid Hemorrhage

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Video Summary

Dr. Kevin Kwan from Northwell provides a presentation on the potential use of macrophage inhibitory factor (MIF) as a biomarker for vasospasm and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. MIF is a cytokine that contributes to vasoconstriction, and the study aims to assess its predictive value in patients with subarachnoid hemorrhage. MIF levels were found to be significantly elevated in subarachnoid patients compared to control patients. The study also found a correlation between the peak MIF level and the onset of clinical vasospasm. However, the presence of infection in some patients may complicate the interpretation of MIF as a biomarker. Further research is needed to explore the potential therapeutic implications of targeting MIF.

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Kevin Kwan, MD

Keywords

macrophage inhibitory factor

biomarker

vasospasm

delayed cerebral ischemia

subarachnoid hemorrhage