2018 AANS Annual Scientific Meeting-636. Hypopituitarism after Gamma Knife Radiosurgery for Pituitary Adenomas: A Multicenter, International Study

636. Hypopituitarism after Gamma Knife Radiosurgery for Pituitary Adenomas: A Multicenter, International Study

Video Transcription

Video Summary

In this video, Dr. Joe Cordero discusses the occurrence of hypopituitarism after gamma knife radiosurgery for pituitary adenomas. The study was conducted at 17 international centers from 1988 to 2016. They analyzed 1,023 patients who had previous radiation therapy excluded from the analysis. The majority of patients had non-functioning pituitary adenomas, Cushing's disease, or acromegaly. The median age was 47, and most patients had undergone previous surgeries. The study found that hypopituitarism was the most frequent adverse effect, occurring in 24.2% of patients. The time to new onset of hypopituitarism varied, with most cases occurring within the first five years after treatment. Patients treated with an iso-dose line less than 50% had a higher risk of developing endocrine deficiencies. Overall, the study suggests that treating the target with an iso-dose line of 50% or greater and avoiding wholesale radiation can help reduce the risk of post-gamma knife radiosurgery hypopituitarism. Long-term follow-up is necessary as patients can develop new hypopituitarism even after 10 years.

Asset Caption

Diogo Cordeiro, MD

Keywords

hypopituitarism

gamma knife radiosurgery

pituitary adenomas

endocrine deficiencies

iso-dose line