2018 AANS Annual Scientific Meeting-638. Stereotactic Radiosurgery for the Management of Acromegaly: Outcomes of a Multicenter Retrospective Cohort Study

638. Stereotactic Radiosurgery for the Management of Acromegaly: Outcomes of a Multicenter Retrospective Cohort Study

Video Transcription

Video Summary

In this video, Dr. Dale Ding discusses the use of stereotactic radiosurgery for the management of acromegaly. The study aimed to assess the outcomes of radiosurgery for acromegaly patients with residual or recurrent tumors. Data was pooled from 10 participating centers and analyzed for baseline and outcomes data. The study cohort consisted of 371 patients, with an average age of 46. The study found that the initial endocrine remission rate was 69% at 10 years and 74% at 15 years. Predictors of remission included lower pre-SRS IGF-1 levels and cessation of medication. The study also found that about 25% of patients developed new endocrinopathies after SRS. It was concluded that radiosurgery can provide durable endocrine remission for half of acromegaly patients, but long-term endocrine follow-up is critical. It is recommended that patients temporarily stop IGF-1 lowering medications prior to SRS to potentially improve its efficacy.

Asset Caption

Dale Ding, MD

Keywords

stereotactic radiosurgery

acromegaly

residual tumors

recurrent tumors

endocrine remission