2018 AANS Annual Scientific Meeting-639. Intraoperative Assessment of Meningioma Proliferative Potential Revealed Intratumoral Heterogeneity and Its Relevance to Biological Characteristics

639. Intraoperative Assessment of Meningioma Proliferative Potential Revealed Intratumoral Heterogeneity and Its Relevance to Biological Characteristics

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Video Summary

Dr. Soichi Oya from Saitama Medical University in Japan discusses the use of intraoperative flow cytometry as a substitute for the MIB1 labeling index in meningioma surgeries. He explains that while maximum safe resection is important, the biological features of tumors influence recurrence rates and overall prognosis more significantly. Intraoperative flow cytometry allows for the evaluation of DNA content and cell count in tumor specimens, providing information about the proliferation index. Dr. Oya presents data showing a correlation between the proliferation index and the MIB1 labeling index, as well as tumor growth rate and intratumoral heterogeneity. He suggests that this method can help guide surgical strategies and aid in the selection of patients for upfront radiosurgery. The limitations and future perspectives of this technique are also discussed. (Transcript credit: Dr. Soichi Oya)

Asset Caption

Soichi Oya, MD, IFAANS (Japan)

Keywords

intraoperative flow cytometry

MIB1 labeling index

meningioma surgeries

tumor specimens

proliferation index