2018 AANS Annual Scientific Meeting-640. Repeat Stereotactic Radiosurgery for Cushing’s Disease: Outcomes of an International, Multicenter Study

640. Repeat Stereotactic Radiosurgery for Cushing’s Disease: Outcomes of an International, Multicenter Study

Video Transcription

Video Summary

Dr. Mehta presents the results of an international multi-center study on repeat stereotactic radiosurgery for Cushing's Disease. Cushing's Disease is caused by pituitary adenomas that produce ACTH and lead to cortisol hypersecretion. While transfronatal surgery is the primary treatment, alternate therapies like radiation therapy are sometimes necessary due to small lesion sizes and sinus invasion. Previous studies have shown remission rates, but also reported adverse effects like hypopituitarism. This study focuses on the outcomes of repeat radiosurgery, finding that it can achieve durable endocrine remission in about half of patients, but it is difficult to assess its effects on the pituitary gland and new endocrinopathies. The recommendation is to reserve repeat radiosurgery for patients with demonstrated hypercortisolemia for at least one year after initial treatment.

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Gautam Unmeel Mehta, MD

Keywords

repeat stereotactic radiosurgery

Cushing's Disease

pituitary adenomas

endocrine remission

hypercortisolemia