2018 AANS Annual Scientific Meeting-643. ABC Transporter Inhibition Plus Vessel Permeability Reduction Enhances the Efficacy of CED in DIPG

643. ABC Transporter Inhibition Plus Vessel Permeability Reduction Enhances the Efficacy of CED in DIPG

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Video Summary

Dr. Zvankin presents a study on enhancing the efficacy of convection-enhanced delivery (CED) in diffuse intrinsic pontine glioma (DIPG). DIPG is a highly infiltrative and inoperable brain tumor that is difficult to treat due to the blood-brain barrier and ABC transporters. The study focuses on using dasatinib, an inhibitor of the PDGF receptor, and teriquidar, an ABC transporter inhibitor, to improve drug-tumor interaction. In vitro and animal models demonstrated increased cell viability and survival rates with dasatinib and teriquidar treatments. Pre-treatment with ABC transporter inhibitor and dexamethasone in CED showed improved drug dispersion, increased apoptosis, and extended survival in DIPG-bearing mice.

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Vadim Tsvankin, MD

Keywords

convection-enhanced delivery

diffuse intrinsic pontine glioma

blood-brain barrier

ABC transporters

dasatinib