2018 AANS Annual Scientific Meeting-644. SYMPHONY: A Novel Synergistic Nanotechnology-Based Platform for the Improvement of Laser Interstitial Thermal Therapy

644. SYMPHONY: A Novel Synergistic Nanotechnology-Based Platform for the Improvement of Laser Interstitial Thermal Therapy

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Video Transcription

Video Summary

Dr. Pakhawat Jongsathit Kiat, a PhD student working in the lab of Dr. Peter Fetchy, discusses the novel synergistic nanotechnology-based platform called Symphony for the improvement of laser interstitial therapy (LIT) in brain tumor treatment. LIT is a minimally invasive tool that uses a laser probe to ablate lesions in the brain. However, it has limitations in terms of range of delivery and lack of specificity. By combining LIT with gold nanostars that act as plasmonic nanoparticles and immunotherapy, the Symphony approach aims to overcome these limitations and activate the immune system for long-term tumor prevention. Preliminary data from mouse models show promising results, and further research is planned for larger animal models and potential translation to clinical applications. The speaker acknowledges the lab members, collaborators, and programs involved. No video credits were specified.

Asset Caption

Pakawat Chongsathidkiet

Keywords

Dr. Pakhawat Jongsathit Kiat

Symphony

nanotechnology-based platform

laser interstitial therapy

brain tumor treatment