2018 AANS Annual Scientific Meeting-711. Effects of Subthalamic Deep Brain Stimulation With Gabapentin and Morphine on Mechanical and Thermal Thresholds in 6-Hydroxydopamine Lesioned Rats

711. Effects of Subthalamic Deep Brain Stimulation With Gabapentin and Morphine on Mechanical and Thermal Thresholds in 6-Hydroxydopamine Lesioned Rats

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Video Transcription

Video Summary

In this video, the speaker, Brian Kazuba, discusses the effects of subthalamic deep brain stimulation (DBS) on pain in Parkinson's disease (PD) patients. He explains that PD patients often experience non-motor symptoms including pain, depression, and sleep disorders. The study conducted on rats with 6-hydroxydopamine lesioned PD focused on using different frequencies of DBS along with gabapentin and morphine to determine their effects on sensory thresholds. The results showed that high-frequency stimulation combined with duloxetine, a medication used for pain management, significantly increased sensory thresholds compared to either intervention alone. The findings suggest a potential additive or synergistic interaction between medication and DBS. The study is further being investigated in clinical settings. This summary is based on a transcript of a speech given in the video, without any specific credits mentioned.

Asset Caption

Brian Kaszuba

Keywords

subthalamic deep brain stimulation

pain

Parkinson's disease

non-motor symptoms

DBS effects