2018 AANS Annual Scientific Meeting-759. Microglia-glioblastoma interactions influence clinical survival

759. Microglia-glioblastoma interactions influence clinical survival

Video Transcription

Video Summary

Dr. Sanjay Dhagun from the University of Minnesota presents a talk on the influence of microglia-glioblastoma interactions on clinical survival. Glioblastoma is a deadly disease, and while patients with mutations in isocitrate dehydrogenase (IDH) have better survival prognoses, some wild-type IDH patients exhibit exceptional responses. The molecular basis of this response is poorly understood. The study found that decreased expression of two inflammatory signatures, Kim and Lewis, was associated with improved survival. Glioblastoma-associated microglia were identified as the principal mediators of these inflammatory signatures. They induce glioblastoma to adopt a stem-cell-like state, leading to increased tumorigenicity and enhanced temozolomide resistance. Inhibiting the PI3K gamma pathway reduced microglia accumulation and increased survival. Targeting microglia-glioblastoma interactions may lead to personalized oncology care. (Transcript from a talk by Dr. Sanjay Dhagun, University of Minnesota)

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Clark C. Chen, MD, PhD, FAANS

Keywords

microglia-glioblastoma interactions

clinical survival

isocitrate dehydrogenase mutations

inflammatory signatures

stem-cell-like state