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2018 AANS Annual Scientific Meeting
760. Outcomes of Adoptive Cell Transfer with Tumor ...
760. Outcomes of Adoptive Cell Transfer with Tumor-Infiltrating Lymphocytes for Metastatic Melanoma Patients with and without Brain Metastases
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Video Transcription
Video Summary
In this video, Gautam Mehta discusses the clinical outcomes of adoptive self-transfer with TILs (tumor-infiltrating lymphocytes) for patients with melanoma brain metastases. Mehta explains that melanoma brain metastases have poor survival rates, and traditional immunotherapy options have limited effectiveness. However, adoptive self-transfer has shown promising results with a response rate of up to 40% in brain metastases. Mehta then presents a study that compares the outcomes of patients with untreated brain metastases to those without brain metastases or with treated brain metastases. The study found that patients with untreated brain metastases had worse progression-free survival and overall survival. Mehta concludes that patients with untreated brain metastases should undergo treatment targeting those sites before receiving adoptive cell transfer immunotherapy.
Asset Caption
Gautam Unmeel Mehta, MD
Keywords
Gautam Mehta
clinical outcomes
adoptive self-transfer
TILs
melanoma brain metastases
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