2018 AANS Annual Scientific Meeting-761. Tumor-Induced Immunosuppression Promotes Brain Metastasis in Patients with Non-Small Cell Lung Cancer

761. Tumor-Induced Immunosuppression Promotes Brain Metastasis in Patients with Non-Small Cell Lung Cancer

Video Transcription

Video Summary

In this video, Derek Lee discusses tumor-induced immunosuppression and its role in promoting brain metastases in patients with non-small cell lung cancer. He presents his research findings on peripheral myeloid PD-L1 expression in patients with brain metastatic lung cancer, showing that it is associated with worse progression-free and overall survival. Lee also explores the role of IL-6 in driving myeloid PD-L1 expression and demonstrates that pharmacologic inhibition of IL-6 can return PD-L1 levels back to baseline. This suggests a potential new immunotherapeutic approach for patients with brain metastatic non-small cell lung cancer. Lee acknowledges the support of his colleagues and funding from the Howard Hughes Medical Institute.

Asset Caption

Yuping Derek Li

Keywords

tumor-induced immunosuppression

brain metastases

non-small cell lung cancer

peripheral myeloid PD-L1 expression

IL-6 inhibition