2018 AANS Annual Scientific Meeting-762. Activation of Canonical EGFR Pathway in Cushing’s Disease

762. Activation of Canonical EGFR Pathway in Cushing’s Disease

Video Transcription

Video Summary

In this video, Jacqueline Boyle, a third-year medical student at the NIH, discusses the role of EGFR activation in Cushing's disease. Cushing's disease is caused by pituitary adenomas that secrete excess ACTH, leading to hypercortisolism. It is known that EGFR is overexpressed in pituitary microadenomas with a USP8 mutation. However, Boyle's research focuses on corticotropanomas with EGFR amplification but lacking a USP8 mutation. Using immunohistochemistry and gene expression microarray analysis, they found increased expression of EGFR and its ligands, amphotericin and noregulin-1, in the adenomas compared to normal tissue. Additionally, metabolic reprogramming and increased glycolysis were observed in the adenomas, potentially driven by EGFR activation. These findings suggest EGFR as a potential target for future treatments of Cushing's disease. <br /><br />No credits were given in the video for the transcript provided.

Asset Caption

Jacqueline Boyle

Keywords

EGFR activation

Cushing's disease

pituitary adenomas

USP8 mutation

gene expression microarray analysis