2018 AANS Annual Scientific Meeting-765. Treatment response assessment maps (TRAMs): increased/decreased sensitivity to tumor/treatment-effects as a function of time post contrast injection

765. Treatment response assessment maps (TRAMs): increased/decreased sensitivity to tumor/treatment-effects as a function of time post contrast injection

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Video Transcription

Video Summary

Dr. Mardor discusses treatment response assessment maps (TRAMs) in this video. TRAMs are used to differentiate tumor from treatment effects. The process involves scanning the patient with T1-weighted MRI five minutes after contrast injection and again at least one hour later. By subtracting the two images, TRAMs are generated. In the TRAMs, red represents treatment effects, while blue represents morphologically active tumor. The sensitivity and specificity of TRAMs for identifying active tumor were found to be 100% and 93% respectively. The video also demonstrates examples of TRAMs in assessing pseudoprogression and progression in patients. The timing of the TRAMs acquisition is crucial for accurate results. The technology is licensed to Brain Lab and is CE and FDA approved.

Asset Caption

Yael Mardor, PhD (Israel)

Keywords

TRAMs

treatment effects

T1-weighted MRI

active tumor

timing of acquisition