2018 AANS Annual Scientific Meeting-766. Subthalamic Nucleus Deep Brain Stimulation Combined with Duloxetine Changes Pain Behavior in Parkinsonian Rats

766. Subthalamic Nucleus Deep Brain Stimulation Combined with Duloxetine Changes Pain Behavior in Parkinsonian Rats

Video Transcription

Video Summary

Miriam Hsiao, a medical student at Dr. Julie Politsis' lab, presents a study on the use of subthalamic nucleus deep brain stimulation (STN-DBS) combined with duloxetine for pain relief in Parkinson's disease (PD) patients. Chronic pain is common in PD and current treatments have limited efficacy. STN-DBS has been shown to provide pain relief, but its effects on pain rather than nociception (sensory detection of noxious stimuli) remain unknown. The study assesses escape avoidance behavior, a measure of pain-related behavior, in PD rats treated with STN-DBS duloxetine. The results suggest that this combination can reduce pain-related behavior, raising the possibility of using the anterior cingulate cortex or the descending inhibitory pain pathway as targets for future PD pain therapies.

Asset Caption

Miriam Mingxuan Shao

Keywords

STN-DBS

duloxetine

pain relief

Parkinson's disease

PD patients