2018 AANS Annual Scientific Meeting-768. Enhanced 5-ALA induced Fluorescence in Hormone Secreting Pituitary Adenomas

768. Enhanced 5-ALA induced Fluorescence in Hormone Secreting Pituitary Adenomas

Video Transcription

Video Summary

In this video, Dr. Akita Bhatnagar discusses the use of 5-ALA (5-aminolevulinic acid) in enhancing the imaging and treatment of pituitary adenomas in Cushing's disease. These microadenomas are often missed on MR imaging due to their small size, but 5-ALA can be used to target and visualize tumor cells. The video shows how 5-ALA, when ingested by the patient and activated by blue light, leads to the emission of red fluorescence specifically in tumor cells, allowing for better surgical outcomes. The study also explores the energy phenotype of pituitary tumor cells and the potential use of 5-ALA in photodynamic therapy. The video concludes by discussing future research directions and acknowledging the study's principal investigator, Dr. Prashant Chiribuena, and the lab at NIH.

Asset Caption

Akrita Bhatnagar

Keywords

5-ALA

pituitary adenomas

Cushing's disease

imaging

treatment