2018 AANS Annual Scientific Meeting-Pathological Network in Essential Tremor and Surgical Implications

Pathological Network in Essential Tremor and Surgical Implications

Video Transcription

Video Summary

In this video, Professor Jean Régis discusses the use of radiosurgery in treating essential tremor. He mentions that initially, radiosurgery was not considered an option for treating essential tremor, but in the 2000s, neurologists started to request radiosurgery for some patients. This led to a dramatic increase in the demand for radiosurgery for tremor, with over 100 cases per year. The targeting for radiosurgery is based on inter-individual targeting, without the use of physiology. A study conducted by the Grenoble Group demonstrated the efficacy and safety of radiosurgery for tremor. The speaker also discusses his research on predicting the outcomes of radiosurgery for tremor. They found that the quantity of gray matter in the occipital area was a predictor of the quality of outcome. Resting state studies showed changes in connectivity in the occipital area after radiosurgery, with decreased connectivity correlating with tremor improvements. The speaker concludes by discussing ongoing research into modeling the abnormal network of central tremor and the need for improved targeting techniques and biomarkers of response.

Asset Caption

Jean Regis, MD (France)

Keywords

radiosurgery

essential tremor

neurologists

efficacy and safety

gray matter