2018 AANS Annual Scientific Meeting-Pharmacogenomics and Pain Control

Video Transcription

Video Summary

In this video, Dr. Morisada discusses pharmacogenetic testing and its application to pain control, specifically focusing on opioids. He explains that pharmacogenomics, the study of how genetics affect drug responses, is the foundation of personalized medicine. In the field of cancer, pharmacogenomics is indispensable for selecting and dosing drugs based on individual genetic makeup. Dr. Morisada argues that a similar approach is needed for pain management, as patients respond differently to opioids based on genetic factors. He explains that opioids need to be activated and metabolized in the body before producing pain relief. The enzymes involved in this process, as well as genetic variations in receptors, can affect the efficacy and toxicity of opioids. Dr. Morisada highlights the importance of understanding patient genetics to improve pain management and reduce adverse drug reactions. He also discusses the challenges of implementing pharmacogenetic testing, including physician unfamiliarity, lack of data, and the need for guidelines. The video concludes with Dr. Morisada explaining the potential benefits of using pharmacogenetic testing to guide pain management decisions and the need for further research in this area.

Asset Caption

Zaman Mirzadeh, MD, PhD

Keywords

pharmacogenetic testing

pain control

opioids

pharmacogenomics

personalized medicine