2018 AANS Annual Scientific Meeting-Report from 2016 Kline Research Awardee: Neuroanatomical Analysis of Distal Surcharge End-to-Side Nerve Repair for In-continuity Nerve Injury in Rodents

Report from 2016 Kline Research Awardee: Neuroanatomical Analysis of Distal Surcharge End-to-Side Nerve Repair for In-continuity Nerve Injury in Rodents

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Video Transcription

Video Summary

In this video, Raj Mehta presents a research study on the neuroanatomical analysis of distal supercharged end-to-side nerve repair for incontinuity nerve injuries in rodents. The study aims to understand the effectiveness of a surgical technique called supercharged end-to-side transfer (SETS) in improving nerve regeneration and functional outcome. The experiment used an animal model of nerve injury and performed a distal end-to-side transfer from the peroneal nerve to the tibial nerve. The results showed that while SETS increased the number of motor neurons regenerating into the tibial nerve, it did not improve functional outcomes. Further analysis revealed that the majority of regenerated motor neurons came from the foreign peroneal nerve pool, indicating limited regeneration from the native nerve. This suggests that SETS with an agonistic donor nerve may be a more effective approach. However, caution is advised as SETS may actually downgrade function unless an appropriate donor is used. The study highlights the need for future research and clinical studies to determine the efficacy of SETS as a treatment for nerve injuries. The video concludes with a question and answer session discussing related topics such as side-to-side anastomosis and stimulation techniques. No credits were mentioned.

Asset Caption

Introduction - Rajiv Midha, MD, MS, FAANS (Canada), Award Recipient - Sudheesh Ramachandran, MD (Canada)

Keywords

neuroanatomical analysis

supercharged end-to-side nerve repair

incontinuity nerve injuries

rodents

surgical technique