2018 AANS Annual Scientific Meeting-Trial Design in Functional Neurosurgery

Video Transcription

Video Summary

The video features Samir Sheth discussing trial design in the field of functional neurosurgery. He begins by acknowledging the increasing use and exploration of neuromodulation, particularly deep brain stimulation (DBS), for various neurologic and psychiatric disorders. The funding from initiatives like the Brain Initiative and NIH, as well as patient demand, have contributed to this trend. Sheth then delves into the importance of designing trials to demonstrate the effectiveness of these treatments. He focuses on two areas: movement disorders and psychiatric disorders. He discusses the use of randomized controlled trials (RCTs) as the gold standard for demonstrating effectiveness, and explains the design and challenges of conducting RCTs in functional neurosurgery. Sheth discusses the use of DBS in both movement and psychiatric disorders and highlights several important trials and their results. He concludes by suggesting alternative trial designs that may be more suitable for certain disorders and acknowledges the need for collaboration with regulatory agencies to determine the acceptability of these designs.

Asset Caption

Sameer A. Sheth, MD, PhD, FAANS

Keywords

trial design

functional neurosurgery

DBS

movement disorders

psychiatric disorders