2018 AANS Annual Scientific Meeting-Whole-Sellar Stereotactic Radiosurgery for Cushing’s Disease: Results from a Multicenter, International Cohort Study

Whole-Sellar Stereotactic Radiosurgery for Cushing’s Disease: Results from a Multicenter, International Cohort Study

Video Transcription

Video Summary

Dr. Matthew Shepard presents findings from a multicenter international cohort study on the outcomes of wholesaler stereotactic radiosurgery for Cushing's disease. While surgery is the main treatment for Cushing's disease, some patients do not achieve long-term remission, leading to significant health consequences. Stereotactic radiosurgery has been used as an adjuvant treatment, but challenges arise in targeting the treatment due to the lack of identifiable adenoma and microscopic invasion. The study analyzed data from 278 patients who underwent stereotactic radiosurgery, including 68 patients who received wholesaler treatment. Remission rates were achieved in 63.2% of patients who received wholesaler treatment, and recurrence rates were relatively low. The study suggests that wholesaler stereotactic radiosurgery is effective in controlling Cushing's disease and should be considered in cases without identifiable adenoma or concerns of local invasion. The study also found that the rates of endocrinopathy were not higher in patients receiving wholesaler treatment compared to those receiving discrete adenoma-targeted therapy.

Asset Caption

Matthew Shepard, MD

Keywords

Dr. Matthew Shepard

multicenter international cohort study

wholesaler stereotactic radiosurgery

Cushing's disease

long-term remission