2023 Pharmacology Update for APPs-Neuroprotective Agents (Luis Cava, MD)

Video Transcription

Video Summary

Neuroprotective agents are used to prevent further neuronal damage and save neurons in the brain from irreversible injury. These agents target different cellular pathways to interfere with mechanisms such as inflammatory processes, oxidative stress, and apoptosis. Some examples of neuroprotective agents include calcium channel blockers like nimodipine, glutamate blockers, statins, free radical scavengers, beta blockers, COX-2 inhibitors, and barbiturates. Ketamine is also a promising agent as it blocks NMDA receptors and has shown to control intracranial pressure and prevent post-ischemic neuronal damage. Other measures such as hypothermia can indirectly provide neuroprotection by controlling intracranial pressure. However, the use of these agents is still not standardized due to the need for more research and strong evidence in clinical outcomes. More studies are required to determine the efficacy and utility of neuroprotective agents in different subsets of neurological injuries.

Keywords

Neuroprotective agents

cellular pathways

oxidative stress

intracranial pressure

neurological injuries