2024 AANS Neurosurgical Topics for APPs - On-Demand-Neuroprotective Agent

Neuroprotective Agent – Luis Cava

Video Transcription

Video Summary

The talk discusses neuroprotective agents, focusing on their potential to prevent neuronal damage through mechanisms like reducing oxidative stress and inhibiting apoptosis. While some agents like calcium channel blockers and glutamate blockers show promise, there is still insufficient evidence for widespread use. Various conditions causing secondary neurological injury, such as ischemic strokes and traumatic brain injuries, are explored. Drugs like ketamine, beta blockers, and cyclosporine are considered for their neuroprotective effects. Adjunctive measures like hypothermia are also mentioned. The speaker emphasizes the need for more research and clinical trials to validate these treatments' effectiveness.

Keywords

neuroprotective agents

oxidative stress

ischemic strokes

traumatic brain injuries

clinical trials