49th Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery Archive-Mutational and Gene Expression Landscapes of Two Novel Sonic-Hedgehog Medulloblastoma Sub-Subgroups in Children Under Five Years

Mutational and Gene Expression Landscapes of Two Novel Sonic-Hedgehog Medulloblastoma Sub-Subgroups in Children Under Five Years - Peter Adidharma

Video Transcription

Video Summary

In the video, Peter Darma, a final medical student at the University of Indonesia, presents his work on the mutational engine expression of two subgroups of medulloblastoma, a malignant pediatric brain tumor. Medulloblastoma accounts for 10% of childhood cancer deaths, with a worse prognosis for children under 5 years old. The two subgroups discussed are Sonic 1 and Sonic 2. Through differential gene expression analysis, it was found that these subgroups differ in gene expression and mutational levels. The anti-PAX3 antibody showed 100% accuracy in differentiating the subgroups. Further research is needed to explore the clinical relevance of these findings. No credits were mentioned in the video.

Keywords

Peter Darma

University of Indonesia

medulloblastoma

Sonic 1

Sonic 2