AANS Beyond 2021: Full Collection-Serial Connectome Mapping of Domain-General Higher Order Cognition Cortical Neurosurgery

Serial Connectome Mapping of Domain-General Higher Order Cognition Cortical Neurosurgery

Video Transcription

Video Summary

In this video, the speaker discusses the importance of serial connectome mapping in understanding higher-order cognition in neurosurgery. They highlight the challenges faced by patients with brain tumors, including memory and cognitive problems, and the annual death toll attributed to brain tumors in the UK. The connectome is described as a brain wiring diagram that helps clinicians think about cognition and relate it to cognitive outcomes. The speaker presents findings from a study using healthy individuals and patients undergoing glioma surgery, showing the activation of specific brain regions during different tasks and the correlation between cortical thickness and executive function performance. They also discuss the infiltration of gliomas in the frontal parietal system and its impact on cognitive function. The optimal time for cognitive rehabilitation is identified as the post-operative to month 3 period, and the decrease in modularity immediately after surgery was found to be associated with long-term cognitive deficits. The implications of this research include a systematic approach to maximizing surgery and improving cognitive outcomes. The video concludes with acknowledgments to supervisors, funding organizations, and team members.

Keywords

serial connectome mapping

higher-order cognition

neurosurgery

brain tumors

cognitive function