AANS Beyond 2021: Scientific Papers Collection-Carboxyl Terminal Modulator Protein Knockout Mitigates Denervation Atrophy in a Mouse Model of Sciatic Nerve Injury

Carboxyl Terminal Modulator Protein Knockout Mitigates Denervation Atrophy in a Mouse Model of Sciatic Nerve Injury

Video Transcription

Video Summary

In this video, Chris Wilson from Indiana University presents research on the role of carboxyl terminal modulator protein (CTMP) in mitigating denervation atrophy in a mouse model of sciatic nerve injury. CTMP inhibits AKT kinase activation, which promotes cell survival. The study found that CTMP expression is downregulated in glioblastoma cell lines, leading to increased AKT activation. To test their hypothesis, the researchers evaluated wild-type mice and CTMP knockout mice after sciatic nerve injury. They discovered that knockout mice experienced less muscle atrophy compared to wild-type mice. The study suggests that CTMP knockout reduces muscle atrophy through mechanisms such as reducing atrophy-promoting genes and inflammatory responses, and increasing anabolic pathways. Ongoing studies include cell culture, axonal regeneration, and functional analysis.

Keywords

carboxyl terminal modulator protein

CTMP

denervation atrophy

sciatic nerve injury

AKT kinase activation