AANS Beyond 2021: Scientific Papers Collection-Characterization of the Minimal Residual Disease in Human Glioblastoma

Characterization of the Minimal Residual Disease in Human Glioblastoma

Video Transcription

Video Summary

In this video, Maliha Ghazi, a medical student and recent PhD graduate, discusses her work on developing a model for glioblastoma (GBM) recurrence and characterizing the minimal residual disease (MRD) state. She expresses gratitude to various labs and individuals for their contributions and funding sources. Ghazi explains that despite aggressive therapy, GBM patients experience disease relapse, and it is unknown whether the recurrence is due to resistant populations or therapy-driven events. She describes the development of a patient-derived xenograft model to monitor tumor growth and analyze tumor cells during treatment. By tracking individual tumor cells using a barcoding strategy, Ghazi observes changes in clonal diversity and identifies different modes of recurrence. She concludes by discussing the potential clinical and therapeutic insights gained from profiling MRD and the prognostic value of an immunomodulatory signature in GBM. The video was presented at an AANS meeting.

Keywords

Maliha Ghazi

medical student

glioblastoma recurrence

minimal residual disease

patient-derived xenograft model