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AANS Beyond 2021: Scientific Papers Collection
Neurosurgery In Press Stereotactic & Functiona ...
Neurosurgery In Press Stereotactic & Functional Neurosurgery Update
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Video Summary
In this video, Professor Aviva Yabash discusses ongoing clinical trials in stereotactic and functional neurosurgery. The COVID-19 pandemic has had a significant impact on surgical volume and patient recruitment for clinical trials at the University of Nebraska Medical Center. Professor Yabash focuses on clinical trials for the treatment of Parkinson's disease, epilepsy, dementia, and tinnitus. In Parkinson's disease, gene therapy trials involving the AADC enzyme have shown safety and modest improvements in symptoms. Voyager Therapeutics' Phase 1B trial using the VY-AADC gene therapy vector has shown promising results in terms of motor function improvement and reduction in medication requirements. However, the trial is currently on hold due to MRI abnormalities observed in some participants. In epilepsy, the RNS system (responsive neurostimulation) has shown ongoing efficacy in reducing seizure frequency over a nine-year period. The use of deep brain stimulation in the fornix has shown potential in slowing cognitive decline in patients with Alzheimer's disease. Finally, caudate stimulation has shown promise in reducing tinnitus loudness, but further research is needed to refine targeting. Overall, these ongoing clinical trials hold promise for improving treatments in neurosurgery, but more research and data are needed to fully understand their efficacy and safety.
Keywords
clinical trials
Parkinson's disease
gene therapy
epilepsy
Alzheimer's disease
tinnitus
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