AANS Online Scientific Session: Stereotactic & Functional-Frameless MLC-based Linear Accelerator Radiosurgical Thalamotomies are Safe and Effective - Early Results of Prospective Phase I/II Clinical Trial

Frameless MLC-based Linear Accelerator Radiosurgical Thalamotomies are Safe and Effective - Early Results of Prospective Phase I/II Clinical Trial

Video Transcription

Video Summary

In this video, Evan Thomas, a radiation oncology resident at the University of Alabama at Birmingham, presents the results of a prospective phase 1-2 clinical trial on frameless MLC-based linear accelerator radiosurgical thalamotomies. The trial aimed to assess the safety, efficacy, toxicity, and quality of life changes for patients with essential tremor or tremor-dominant Parkinson's disease. The technique involved non-invasive radiosurgery without a stereotactic frame, using a thermoplastic mask and an optical surface monitoring system for patient immobilization and motion detection. The treatment planning involved targeting the ventral intermediate nucleus of the thalamus with a precise radiation dose distribution. The results showed significant tremor reduction in the majority of patients, indicating the effectiveness of the treatment. The technique was found to be safe, efficient, and reproducible, prompting further funding for the trial. This summary is based on the transcript of the video lecture by Evan Thomas.

Asset Subtitle

Evan Thomas

Keywords

radiation oncology

MLC-based linear accelerator

thalamotomies

essential tremor

Parkinson's disease