AANS Online Scientific Session: Stereotactic & Functional-Potential therapeutic mechanism of centromedian-parafascicular complex deep brain stimulation in Tourette syndrome

Potential therapeutic mechanism of centromedian-parafascicular complex deep brain stimulation in Tourette syndrome

Video Transcription

Video Summary

In this video, Aaron Rasheen, an MD-PhD candidate at the Mayo Clinic, presents his research on the potential therapeutic mechanism of central median paraphysicular complex stimulation (CMPF-DBS) for Tourette syndrome. He explains that CMPF-DBS has been shown to be beneficial for Tourette syndrome patients, but the underlying neurobiological mechanism is not well understood. Rasheen's research focuses on understanding how CMPF-DBS modulates striatal dopamine, leading to the alleviation of tics. He conducted experiments on anesthetized rats, using techniques like functional MRI imaging and voltammetry to measure dopamine release in response to stimulation. The results show that CMPF-DBS evokes both phasic and tonic dopamine release, with the release being dependent on stimulation location, frequency, and amplitude. Rasheen concludes that his findings contribute to a better understanding of the therapeutic potential of CMPF-DBS for Tourette syndrome.

Asset Subtitle

Aaron Elliott Rusheen

Keywords

CMPF-DBS

Tourette syndrome

dopamine release

stimulation location

therapeutic potential