Best of the AANS Session-A randomized trial of corticosteroids versus placebo in the conservative management

A randomized trial of corticosteroids versus placebo in the conservative management

Video Transcription

Video Summary

In this video presentation, the results of a trial on chronic subdural hematomas and corticosteroids are discussed. Chronic subdural hematoma is a common condition caused by inflammation after a traumatic event, and corticosteroids have been proposed as an alternative to surgery. However, there is a lack of high-level studies on their efficacy. The trial design involved randomizing patients into a placebo group or a group receiving methylprednisolone. The primary endpoint was the occurrence of surgery at one month, and secondary endpoints included overall survival, quality of life, and cognitive evaluations. The study found that methylprednisolone decreased the need for surgery, but the spontaneous healing rate of these hematomas was 82%. There were significant side effects associated with methylprednisolone, so the risk-benefit balance must be carefully considered for each patient.

Keywords

chronic subdural hematoma

corticosteroids

trial results

methylprednisolone

surgery